An ancient city of Phrygia near the Orontes River and modern Yalvaç in Turkey. It was founded in 300 BC by Seleucus I (c 358-281 BC) after the death of Alexander the Great and was one of the two capitals of the Parthian Empire. It became a Roman city in 64 BC at the hands of Pompey and served as a capital of the province of Syria and was one of the three most important cities of the Roman world. Antioch peaked under Hadrian as a civil and military administrative center, then suffered Persian invasions during the 3rd century AD. It was rebuilt by Diocletian and successive emperors form the 4th century AD. The plain of Anitoch was occupied from the Neolithic onwards. Its ruins include a large rock cutting which may have held the temple of Men Ascaënus, the local Phrygian deity.